CJA
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Submit a scholarly reply
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by COOPER, G. M.
Right arrow Articles by ALAGHBAND-ZADEH, J.
Right arrow Search for Related Content
PubMed
Right arrow Articles by COOPER, G. M.
Right arrow Articles by ALAGHBAND-ZADEH, J.

Canadian Journal of Anesthesia, Vol 26, 381-385, Copyright © 1979 by Canadian Anesthesiologists' Society

Epidural Analgesia and the Metabolic Response to Surgery

GRISELDA M. COOPER M.B., Ch.B., F.F.A.R.C.S.1, ANITA HOLDCROFT M.B., Ch.B., F.F.A.R.C.S.1, G. M. HALL M.B., B.S., Ph.D., M.I.Biol., F.F.A.R.C.S.1, and J. ALAGHBAND-ZADEH L.M.S.S.A., M.R.C.Path.2

1 Department of Anaesthetics, Royal Postgraduate Medical School, Hammersmith Hospital, London, W.12, OHS, England
2 Department of Chemical Pathology, Charing Cross Hospital Medical School, London, W.12, England

Correspondence to: Dr. G.M. Hall, Department of Anaesthetics, Royal Postgraduate Medical School, Hammersmith Hospital, London. W.12, OHS. England.

The effect of epidural blockade on the metabolic and hormonal responses to pelvic surgery was investigated in 14 female patients. Central venous blood samples were collected every 30 minutes and analysed for free fatty acids, glycerol, ({beta}-hydroxybutyrate, acetoacetate, glucose, lactate, pyruvate, cortisol and growth hormone concentrations. There was no change in fat and glucose metabolism except for a transient decrease in lipolysis after 30 minutes of surgery. Cortisol and growth hormone values were significantly increased (p < 0.01) after 60 minutes. A small but statistically significant increase in blood lactate concentration was observed (p< 0.01) and the concept of a "metabolic V·/Q·" abnormality is postulated to explain the lacticacidaemia.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1979 by the Canadian Anesthesiologists' Society.