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Canadian Journal of Anesthesia, Vol 26, 410-414, Copyright © 1979 by Canadian Anesthesiologists' Society

Can Naloxone Inhibit the Cardiovascular Effect of Acupuncture?

D. C. LEE 1, K. ICHIYANAGI 2, M. O. LEE 3, D. H. CLIFFORD 3, and L. E. MORRIS 3

1 Departments of Anesthesia, Physiology and Anatomy and the Division of Laboratory Animal Medicine, Medical College of Ohio, C.S. #10008, Toledo, Ohio 43699, U.S.A.
2 Department of Anesthesia, School of Medicine, Yamagata University, Yamagata, Japan
3 Departments of Anesthesia, Physiology and Anatomy and the Division of Laboratory Animal Medicine, Medical College of Ohio, C.S. # 10008, Toledo, Ohio 43699, U.S.A.

Forty dogs were studied during MAC-1 halothane anaesthesia with a chronically implanted electromagnetic flow probe on the ascending aorta. Cardiac output, stroke volume, heart rate, mean arterial pressure, pulse pressure, central venous pressure and total peripheral resistance were determined in addition to PaOO2. pH, PaCOCO2 and base deficit.

Acupuncture moxibstion with electrocautery at Jen Chung (Go-26) produced a significant (five per cent level) increase in the cardiac output, stroke volume, heart rate, mean arterial pressure and pulse pressure and a significant decrease in total peripheral resistance during a 120-minute period of observation in dogs under halothane anaesthesia. Acupuncture moxibustion at Go-26 following pretreatment with the narcotic antagonist naloxone (1 mg·kg-1) produced a significant increase in cardiac output, heart rate, mean arterial pressure, pulse pressure and central venous pressure. It is concluded that naloxone, which inhibits the analgesic effects of acupuncture, does not inhibit the sympathomimetic effect of acupuncture or moxibustion at Jen Chung (Go-26) in dogs under light MAC-1 halothane anaesthesia.






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Copyright © 1979 by the Canadian Anesthesiologists' Society.