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Canadian Journal of Anesthesia, Vol 26, 479-481, Copyright © 1979 by Canadian Anesthesiologists' Society

Effect of Pancuronium on Intraocular Pressure Changes Induced by Succinylcholine

HALAPPA N. KONCHIGERI 1, YONG EUN LEE 1, and KOTTARATHIL VENUGOPAL 1

1 Department of Anesthesiology, Abraham Lincoln School of Medicine, University of Illinois Hospitals, 840 South Wood Street, Chicago, Illinois 60612, U.S.A.

The study was undertaken to evaluate the influence of pretreatment with a small dose of pancuronium on intraocular pressure changes associated with administration of succinylcholine and tracheal intubation. Thirty patients divided into control and study groups were anaesthetized with sodium thiopentone (3-5 mg·kg-1) and intubation with the aid of succinylcholine (1 mg·kg-1).

The control group received saline pretreatment while the study group received pancuronium 1 mg three minutes before succinylcholine. Anaesthesia was maintained with nitrous oxide and oxygen (70:30). A Schiotz tonometer was used to measure intraocular pressure before induction of anaesthesia, one minute after succinylcholine and immediately after intubation.

Patients in the control group demonstrated significant elevation of intraocular pressure at one minute after succinylcholine and immediately after intubation, while the study group showed no significant changes at the same observation periods.

These findings indicate that pretreatment with pancuronium 1 mg three minutes before succinylcholine may be beneficial in patients with high intraocular pressure and penetrating injuries of the eye.







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Copyright © 1979 by the Canadian Anesthesiologists' Society.