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Canadian Journal of Anesthesia, Vol 26, 484-488, Copyright © 1979 by Canadian Anesthesiologists' Society

Does Prior Dantrolene Affect the in Vitro Diagnosis of Malignant Hyperthermia Susceptibility?

T. E. NELSON 1 and E. H. FLEWELLEN 1

1 Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas 77550, U.S.A.

A therapeutic and prophylactic dose of dantrolene administered to malignant hyperthermia-susceptible pigs had no effect on the abnormal in vitro contracture response of subsequent muscle biopsies. The in vitro contracture response of MHS pig muscle to halothane and to caffeine was not altered by prior dantrolene treatment. It is concluded that prior dantrolene administration has no effect on the discrimination of porcine MHS by in vitro pharmacological testing.






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Copyright © 1979 by the Canadian Anesthesiologists' Society.