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Canadian Journal of Anesthesia, Vol 27, 12-15, Copyright © 1980 by Canadian Anesthesiologists' Society

Comparison of Effects of Several Inhalation Anaesthetics on Caffeine-Induced Contractures of Normal and Malignant Hyperthermic Skeletal Muscle

BEVERLEY A. BRITT 1, LASZLO ENDRENYI 2, WANDA FRODIS 3, ELIZABETH SCOTT 3, and WERNER KALOW 4

1 Department of Anaesthesia, University of Toronto; Department of Pharmacology, University of Toronto; Toronto General Hospital, Toronto, Ontario, Canada
2 Department of Pharmacology, University of Toronto; Department of Preventive Medicine and Biostatistics, University of Toronto, Toronto, Ontario, Canada
3 Department of Anaesthesia
4 Department of Pharmacology, University of Toronto

We have compared the combined effects of halothane, enflurane, isoflurane and methoxyflurane on caffeine-induced contractures of normal and malignant hyperthermia susceptible (MHS) skeletal muscle fascicles. We have found that caffeine contractures without and with the addition of any of these four anaesthetics are higher in MHS than in normal muscle. The differences between the normal and MHS muscle are about the same for all drug combinations. For all four anaesthetics the degree of increase of the contracture is about the same in the normal as in the MHS muscle. For both the MHS and the normal muscle the caffeine contractures are from greatest to least: halothane > isoflurane > enflurane > methoxyflurane. Examination of the relationships among the caffeine specific concentrations in the presence of the various anaesthetics shows significant differences for the comparisons of halothane with the other three anaesthetics but, for the most part, the comparisons among methoxyflurane, enflurane and isoflurane are not meaningful statistically.






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Copyright © 1980 by the Canadian Anesthesiologists' Society.