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Canadian Journal of Anesthesia, Vol 27, 36-39, Copyright © 1980 by Canadian Anesthesiologists' Society

Reduction of Postoperative Vomiting by Preoperative Administration of Oral Metoclopramide

M. J. DIAMOND 1 and M. KEERI-SZANTO 1

1 University of Western Ontario, Department of Anaesthesia at Victoria Hospital

Preoperative oral metoclopramide was evaluated as a postoperative antiemetic agent.

Two series of approximately one hundred patients were investigated in this context. One series was carefully controlled with regard to anaesthetic agents and technique. The other series had only one criterion of admission-the exclusion of narcotics.

All patients received metoclopramide 20 mg by mouth or a placebo two hours before anaesthesia in a randomized double-blind fashion.

A significant reduction in postoperative symptoms of antiperistalsis was observed in the metoclopramide-treated patients.

On closer scrutiny it became apparent that, under these circumstances, metoclopramide is significantly more effective in males.






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Copyright © 1980 by the Canadian Anesthesiologists' Society.