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Canadian Journal of Anesthesia, Vol 27, 47-51, Copyright © 1980 by Canadian Anesthesiologists' Society

Effects of Ketamine and Halothane on Normal and Asthmatic Smooth Muscle of the Airway in Guinea Pigs

ALFREDO CABANAS , JOSEPH F. SOUHRADA 1, and J. ANTONIO ALDRETE 2

1 Pulmonary Physiology Laboratory, National Jewish Hospital and Research Center
2 Department of Anesthesiology, University of Colorado School of Medicine, Denver, Colorado, U.S.A.

Address all correspondence to: J. Antonio Aldrete, M.D., M.S., Department of Anesthesiology (B 113), University of Colorado Medical Center, Denver, Colorado, 80262, U.S.A.

In vitro preparations of trachea isolated from normal and asthmatic guinea pigs were used to measure their maximum contractile response to histamine challenge and to determine spontaneous relaxation of smooth muscle of the airway. The effect of ketamine and halothane on these reactions was investigated. The optimal ketamine concentration was found to be 10 µg/ml. This dose attenuated the maximum contraction and produced greater relaxation (p < 0.01) of isolated trachea. However, ketamine failed to prevent an anaphylactic (Schultz-Dale) response when antigen (one per cent albumin) was added in an experimental chamber containing pre-sensitized guinea pig trachea. In contrast, halothane abolished any response to histamine challenge and prevented development of the Schultz-Dale response of smooth muscle from the airway of asthmatic guinea pigs.

Note:

From the Departments of Anesthesiology and Medicine, University of Colorado School of Medicine and the National Jewish Hospital and Research Center, Denver, Colorado.






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Copyright © 1980 by the Canadian Anesthesiologists' Society.