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Canadian Journal of Anesthesia, Vol 27, 279-282, Copyright © 1980 by Canadian Anesthesiologists' Society

Severe Muscular Rigidity at Birth: Malignant Hyperthermia Syndrome?

K. SEWALL 1, R.M. M. FLOWERDEW 1, and P. BROMBERGER 1

1 Maine Medical Center, Portland, Maine 04102, U.S.A.

A case of severe muscular rigidity in a premature male infant born by Caesarean Section under general anaesthesia is described. A probable diagnosis of malignant hyperthermia was supported by the clinical symptoms of muscular rigidity and cyanosis, a creatinine phosphokinase of 24,630 I.U. (Normal 0-100) and a urinary myoglobin of 248 mg/I (normal 6-35). The muscle tone and laboratory values slowly returned to normal over a period of days. Anaesthetic management for a ventriculoperitoneal shunt performed at seven weeks of age included pre and postoperative treatment with dantrolene. No crisis occurred at this time. The parents, who have normal CPK and a negative family history, were advised to treat the child as if he had malignant hyperthermia until such time as a definitive diagnosis can be made.






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Copyright © 1980 by the Canadian Anesthesiologists' Society.