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Canadian Journal of Anesthesia, Vol 27, 351-356, Copyright © 1980 by Canadian Anesthesiologists' Society
1 Department of Anesthesiology, The University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78284.
2 University of Pittsburg
3 Department of Anesthesiology, The University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78284
Please address correspondence to: R. Brian Smith, M.D., Professor and Chairman, Department of Anesthesiology, The University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78284.
A study was undertaken on dogs to find the limit of carbon dioxide exchange with high frequency jet ventilation using a fluidic logic controlled oxygen jet ventilator. Fifteen dogs were ventilated through a transtracheal catheter at respiratory rates up to 600 per minute. The following were recorded: aortic, pulmonary artery, pulmonary arterial wedge, and central venous blood pressures; intratracheal pressure; electrocardiogram; inspiratory and expiratory time of the jet; arterial and central venous blood gases; intermittent cardiac output.
Normal gas exchange was found up to a respiratory rate of 400 per minute with low tidal volume and low intratracheal pressures. There were no adverse circulatory effects up to a rate of 400 per minute. At rates of 500 and 600 per minute, cardiac contractility was unaffected, but a decreased heart rate and increased peripheral resistance produced a fall in cardiac output. There was no interference with the resumption of spontaneous ventilation during weaning.
In a control series of five dogs, apnoeic oxygenation was used. The PaCOCO2 was allowed to reach 15.96 kPa (120 torr). High frequency jet ventilation was then started at a rate of 600 per minute and decreased in increments to 100 per minute. Arterial blood gases were continuously recorded through an intra-arterial catheter connected to a mass spectrometer. The PaCOCO2 gradually declined to normal levels as the rate decreased.
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