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Canadian Journal of Anesthesia, Vol 27, 440-444, Copyright © 1980 by Canadian Anesthesiologists' Society

The "Milieu Interieur" - A Model of Brain Physiology and Pathophysiology

JOHN G. WADE 1

1 Department of Anaesthesia, Faculty of Medicine, University of Manitoba, Health Sciences Centre - General, 700 William Avenue, Winnipeg, Manitoba, R3E 0Z3

The "milieu interieur" or "internal environment" of the brain is determined by the glial cells, the cerebrospinal fluid, the blood-brain barrier, the cerebral blood flow, the central regulation of respiration, and the intracranial pressure. Anaesthetic agents and anoxia-ischaemic insult can disrupt this important but vulnerable neuronal environment. Head injury is used as an example of a common insult to the neuronal environment and the principles of management are discussed, using a model of brain physiology and pathophysiology which can be modified to include other clinical situations.






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Copyright © 1980 by the Canadian Anesthesiologists' Society.