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Canadian Journal of Anesthesia, Vol 27, 449-452, Copyright © 1980 by Canadian Anesthesiologists' Society

Bleomycin and Subsequent Anaesthesia: A Retrospective Study at Vancouver General Hospital

M. J. DOUGLAS 1 and C.M. L. COPPIN 2

1 Department of Anaesthesia, Vancouver General Hospital, Vancouver, B.C.
2 Department of Medicine, Vancouver General Hospital and Division of Medical Oncology, Cancer Control Agency of British Columbia, Vancouver, B.C.

A retrospective review was made of 20 surgical procedures in 14 patients with testicular carcinoma, previously treated with bleomycin chemotherapy, to evaluate the incidence of postoperative pulmonary complications. Other studies have suggested an increased rate of pulmonary complications, including fatal respiratory failure, when inspired oxygen fraction (Fioo2) exceeds 0.3 during or after operation. There is a suggestion that bleomycin may sensitize the lungs to the effect of oxygen, leading to oxygen toxicity. This study involved patients whose inspired oxygen fraction ranged from 0.3 to 1.0 and only one non-fatalpulmonary complication occurred. The risks of anaesthesia following bleomycin are discussed with particular reference to possible enhanced oxygen toxicity.






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Copyright © 1980 by the Canadian Anesthesiologists' Society.