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Canadian Journal of Anesthesia, Vol 27, 496-499, Copyright © 1980 by Canadian Anesthesiologists' Society

Mechanism for Gastric Accumulation of Meperidine and Effect of Antacid

R. J. TRUDNOWSKI 1 and T. GESSNER 2

1 Department of Anesthesiology, Roswell Park Memorial Institute, New York State Department of Health, 666 Elm Street, Buffalo, New York, 14263, U.S.A.
2 Department of Experimental Therapeutics, Roswell Park Memorial Institute, New York State Department of Health, 666 Elm Street, Buffalo, New York, 14263, U.S.A.

The effect of hydrogen ion activity (pH) on the degree of meperidine sequestration in gastric contents was studied in 15 patients. Those patients with higher gastric juice cH+ (lower pH) showed greater accumulation with time. At a cH+ more than 10,000 nmol/l, (pH < 5) concentration usually reached 100 µg/ml within the 60-minute period after administration of 200 mg of meperidine. When cH+ was less than 100 nmol/l (pH > 7) gastric concentrations remained low, being only slightly greater than those of plasma. Oral administration of antacid may be a practical method for preventing sequestration of meperidine in gastric juice.






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Copyright © 1980 by the Canadian Anesthesiologists' Society.