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Canadian Journal of Anesthesia, Vol 27, 560-564, Copyright © 1980 by Canadian Anesthesiologists' Society

Plasma Levels and Cardiovascular Effects of Nitroglycerin in Pregnant Sheep

M. DE ROSAYRO 1, M. L. NAHRWOLD 1, A. B. HILL 1, A. R. TAIT 1, M.D. TAYLOR BUSCH 1, and M. M. KIRSH 1

1 The University of Michigan, Ann Arbor, Michigan 48109

The cardiovascular effects and blood levels of intravenous nitroglycerin in mother and foetus were studied in normotensive and hypertensive ewes. Although nitroglycerin produced a reduction in uterine blood flow following a decrease in blood pressure, there was little if any incidence of adverse effects in the foetus. Nitroglycerin was detected in all but two samples of foetal arterial blood but the foetal/maternal artery ratio was only 0.04. Nitroglycerin merits further evaluation for the treatment of acute hypertensive episodes in the preeclamptic patient.






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Copyright © 1980 by the Canadian Anesthesiologists' Society.