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Canadian Journal of Anesthesia, Vol 28, 114-120, Copyright © 1981 by Canadian Anesthesiologists' Society

Effect of 4-Aminopyridine on Cardiovascular Functions in the Dog

É. MARTÍNEZ-AGUIRRE M.D.1, J. A. WIKINSKI M.D.1, A. BELLO M.D.2, J. IZQUIERDO M.D.2, A. GARCIA M.D.3, and HILDA VELARDE M.D.3

1 Department of Anesthesiology, Central University of Venezuela, School of Medicine, Hospital Universitario de Caracas, Venezuela
2 Department of Cardiovascular Surgery, Central University of Venezuela, School of Medicine, Hospital Universitario de Caracas, Venezuela
3 Department of Cardiovascular Surgery. Central University of Venezuela, School of Medicine, Hospital Universitario de Caracas, Venezuela

The drug 4-aminopyridine (4-AP) at a dose of 0.2 mg·kg-1 body weight intravenously is an effective antagonist of non-depolarizing neuromuscular blockade. We studied its cardiovascular effects in the canine heart using a right-heart bypass with extracorporeal circulation in seven dogs. This study demonstrates that 4-aminopyridine significantly augments arterial blood pressure, left ventricular dp/dt maximum, as well as left ventricular pressure at dp/dt mx. The highest values were obtained between two and 20 minutes after administration of 4-AP. Left ventricular end-diastolic pressure diminished slightly, but this was not statistically significant. Although the exact mechanism of action of 4-AP is not known, its positive inotropic effects may be of value in the reversal of non-depolarizing neuromuscular blockade in patients with impaired myocardial function of diverse aetiologies and it would be contraindicated in patients with arterial hypertension and/or coronary artery disease.

Note:

This study was performed at the Myocardial Contractility Laboratory, Experimental Surgery Institute of the Central University of Venezuela, School of Medicine and supported, in part, by CONICIT, grant No S-1-0690, grant from the Council for Scientific and Humanistic Development (CDCH), and a grant from the Vollmer Foundation.

Key Words: ANTAGONISTS, NEUROMUSCULAR RELAXANTS • 4-aminopyridine, cardiovascular effects






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Copyright © 1981 by the Canadian Anesthesiologists' Society.