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Canadian Journal of Anesthesia, Vol 28, 149-152, Copyright © 1981 by Canadian Anesthesiologists' Society

Clinical Trial of Fazadinium Bromide (Fazadon)

C. E. FAMEWO M.B., B.S. Dip. Anaes. (Toronto); F.R.C.P.(C)1

1 Department of Anaesthesia, University of Ibadan and University College Hospital, Ibadan, Nigeria

Fifty healthy Nigerian surgical patients were given fazadinium bromide at a dose level of 10 mg·kg-1 while 30 other similar patients received 1.5 mg·kg-1. Anaesthesia was induced with either thiopentone or alfathesin. Tracheal intubation was satisfactorily accomplished after a mean of 55 seconds with the 1 mg·kg-1 dose and a mean of 32 seconds with the 1.5 mg·kg-1 dose. Duration of action of fazadinium 1 mg·kg-1 was a mean of 42 min (range 30 to 50 min) while the mean for 1.5 mg·kg-1 was 55 min (range 45 to 70 min). There was no significant difference between the thiopentone and alfathesin induction groups. Reversibility with neostigmine was excellent. Whereas the 1 mg·kg-1 dose was satisfactory for normal regular intubation, the 1.5 mg·kg-1 dose is recommended for "crash" intubation. The administration of fazadinium was associated with a stable blood pressure and moderate sinus tachycerdia. No other side effects were seen.

Key Words: NEUROMUSCULAR RELAXANTS, Fazadinium, Neostigmine






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Copyright © 1981 by the Canadian Anesthesiologists' Society.