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Canadian Journal of Anesthesia, Vol 28, 253-258, Copyright © 1981 by Canadian Anesthesiologists' Society

The Influence of Thiopentone and Alfathesin on Succinylcholine-Induced Fasciculations and Myalgias

G. MANANI M.D.1, S. VALENTI M.D.2, A. SEGATTO M.D.2, A. ANGEL M.D.1, M. MERONI M.D.1, and G. P. GIRON M.D.1

1 Institute of Anesthesiology and Resuscitation, University of Padua, Italy
2 Department of Anesthesiology, Motta di Livenza, Treviso, General Hospital, Italy

Address correspondence to: G.P. Giron, Direttore Instituto di Anestesiologia e Rianimazione del l'Università di Padova, Via Giustiniani, 2, 35100 Padova, Italia.

Thiopentone doses corresponding to 5.238 mg·kg-1, that is 2UD95 (UD95: unconsciousness dose 95) inhibit the intensity of succinylcholine-induced fasciculations compared with UD95. Alfathesin doses corresponding to 0.570 mg·kg-1, also 2UD95 (calculated as alphaxalone at a concentration of 9 mg/ml in alfathesin), do not have any greater effect on the degree of fasciculations compared to UD95. Furthermore, neither induction agent influences the incidence, distribution and duration of succinylcholine-induced myalgias. The inhibition of the degree of fasciculations caused by thiopentone is believed to be a consequence of a postsynaptic depressant effect of thiopentone at the neuromuscular junction. The evaluation of the degree of succinylcholine-induced fasciculations must take into consideration the dose of thiopentone administered at induction of anaesthesia.

Key Words: NEUROMUSCULAR RELAXANTS, succinylcholine • MUSCLE, SKELETAL, fasciculation, myalgia • ANAESTHETIC AGENTS, thiopentone, alfathesin






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Copyright © 1981 by the Canadian Anesthesiologists' Society.