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Canadian Journal of Anesthesia, Vol 28, 280-282, Copyright © 1981 by Canadian Anesthesiologists' Society

Excessive Requirement for Heparin during Cardiac Surgery

FRANCES CHUNG M.B., B.S., F.R.C.P.(C)1, TIRONE E. DAVID M.D., F.R.C.S.(C)2, and J. WATT M.D., F.R.C.P.(C)2

1 Department of Anaesthesia, University of Toronto and Toronto Western Hospital, Toronto, Ontario, Canada
2 University of Toronto and Toronto Western Hospital, Toronto, Ontario, Canada

A case of excessive heparin requirement during cardiopulmonary bypass is reported. A patient with sepsis secondary to a myocardial abscess required 13.5 mg·kg-1 of heparin to increase his activated coagulation time to a therapeutic level. This phenomenon might be due to individual variability, lupus vasculitis, septicaemia, repeated thromboembolic phenomenon with hypercoagulable state, or chronic disseminated intravascular coagulation with partial antithrombin deficiency.

Key Words: CARDIAC SURGERY; Heparin, excessive requirement






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Copyright © 1981 by the Canadian Anesthesiologists' Society.