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Canadian Journal of Anesthesia, Vol 28, 339-341, Copyright © 1981 by Canadian Anesthesiologists' Society

The Effect of Nitrous Oxide on Baroreceptor Function in Newborn and Adult Rabbits

P. G. DUNCAN 1, G. A. GREGORY 1, and J. G. WADE 1

1 The Department of Anaesthesiology, University of Manitoba, Health Sciences Centre, 700 William Avenue, Winnipeg, Manitoba, R3E 0Z3 and the Department of Anaesthesiology, University of California, San Francisco, California

The baroreceptor response was evaluated in newborn and adult rabbits by the pressor test of Smyth during the administration of oxygen and nitrous oxide. Newborn rabbits were found to have an attenuated baroreceptor reflex in comparison to adults. In addition, their reflex was more susceptible to the depressant effect of nitrous oxide. The newborn may be particularly at risk of cardiovascular compromise during anaesthesia and acute stress due to the dependence of cardiac output on heart rate.

Key Words: RECEPTORS, baroreceptor function • Nitrous oxide






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Copyright © 1981 by the Canadian Anesthesiologists' Society.