CJA
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Submit a scholarly reply
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by LINDAHL, S.
Right arrow Search for Related Content
PubMed
Right arrow Articles by LINDAHL, S.

Canadian Journal of Anesthesia, Vol 28, 356-362, Copyright © 1981 by Canadian Anesthesiologists' Society

Circulatory and Ventilatory Effects of Hypervolaemia in Artificially Ventilated Piglets

STEN LINDAHL 1

1 Department of Anaesthesia, University Hospital, S-221 85, Lund, Sweden

The influence of hypervolaemia upon circulation and pulmonary ventilation was studied in six piglets (body weights 8.5-10.5 kg). A new functional principle for artificial ventilation was used. The alveolar ventilation was unchanged at normovolaemia and hypervolaemia. Arterial blood gases were sampled and end-tidal carbon dioxide concentrations were measured continuously. Central circulation was followed by pressure recordings and an electromagnetic flow meter for cardiac output measurements.

Mean values ± SEM of end-inspiratory tracheal pressures increased from 0.98 ± 0.06 kPa at normovolaemia to 1.57 ± 0.06 kPa at hypervolaemia (p < 0.02). In all animals total compliance decreased (p < 0.02). Simultaneously the insufflation time for the tidal volume decreased by 13 percent (p < 0.05). Arterial oxygen tensions decreased from 8.5 ± 0.48 kPa to 7.0 ± 0.77 kPa (p < 0.05).

During hypervolaemia aortic pressures increased from 13.1 ± 1.3 kPato 14.9 ± 0.8 kPa(p < 0.05), pulmonary artery pressures from 2.8 ± 0.33 kPa to 5.0 ± 0.53 kPa(p < 0.02) and cardiac output from 1.07 ± 0.17 l·min-1 to 1.5 ±0.19 l·min-1(p < 0.02). The stroke work for the right heart increased by 74 per cent (p < 0.02) and for the left heart by 62 per cent (p < 0.02). Pulmonary vascular resistance was unchanged, while systemic vascular resistance was significantly decreased (p < 0.05).

The positive effect upon systemic circulation gained by the use of excessive fluid therapy resulted in an overcirculation within the lungs which reduced pulmonary ventilation. This reduction could most probably be related to a closure of terminal airways secondary to lung hyperperfusion, increasing the pulmonary shunt.

Key Words: BLOOD, HYPERVOLAEMIA, CIRCULATION, VENTILATION






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1981 by the Canadian Anesthesiologists' Society.