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Canadian Journal of Anesthesia, Vol 28, 442-449, Copyright © 1981 by Canadian Anesthesiologists' Society

Contrôle De L'AciditÉ Gastrique Par la Cimétidine Donnée En Prémédication Avant L'Anesthésie Générale: Efficacité Et Tolérance

D. RICHE 1, CH. CONSEILLER 1, B. COULBOIS 1, D. ORTEGA 1, M-CH. TERESTCHENKO 1, and J-M. PACOURET 1

1 Département d'Anesthésie et de Réanimation Chirurgicale du C.H.U. Paris-Ouest. Hôpital Ambroise Pare. 9, Avenue Ch. de Gaulle 92100-Boulogne/Seine France

Cimetidine 400 mg was administered intramuscularly 60 minutes before the beginning of general anaesthesia. The double blind experiment was conducted on 84 patients divided in two groups: cimetidine and control. There was no difference in gastric fluid volume between the two groups during general anaesthesia, but acid secretion decreased significantly in the cimetidine group. Values of pH lower than 2.5 were observed in 33.3 per cent at induction and 34 per cent at recovery in the control group against 14.6 per cent and 0 per cent in the cimetidine group

Clinical tolerance to cimetidine was studied in 100 patients during operation. Cimetidine did not alter pharmacological action of usual anaesthetics. There were no significant changes in cardiovascular and electrocardiographic data.

Key Words: PREMEDICATION, cimétidine • ACIDITE GASTRIQUE, controle, cimeétidine






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Copyright © 1981 by the Canadian Anesthesiologists' Society.