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Canadian Journal of Anesthesia, Vol 28, 450-452, Copyright © 1981 by Canadian Anesthesiologists' Society

Cimetidine and Prolonged Post-Operative Somnolence

ARTHUR M. LAM 1 and JOHN A. PARKIN 1

1 Department of Anaesthesia, University Hospital and University of Western Ontario, London, Canada

A case of prolonged post-operative somnolence is described. The patient was on concurrent benzodiazepine and cimetidine therapy. Cimetidine can cause impairment of metabolism of the benzodiazepines by inhibiting the hepatic microsomal enzyme system and its possible role in causing the prolonged somnolence is discussed.

Key Words: INTERACTION (DRUG), cimetidine, benzodiazepine






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Copyright © 1981 by the Canadian Anesthesiologists' Society.