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Canadian Journal of Anesthesia, Vol 28, 459-462, Copyright © 1981 by Canadian Anesthesiologists' Society

Effect of Fazadinium (Fazadon) on Muscle Fasciculations Induced by Succinylcholine

C. E. FAMEWO 1

1 College of Medicine, University of Ibadan, University College Hospital, Ibadan, Nigeria

The effects on muscle fasciculations and ease of tracheal intubation of pretreatment with fazadinium before administration of succinylcholine were evaluated in 85 patients. Four dose levels of fazadinium evaluated were 0.05 mg·kg-1, 0.075 mg·kg-1, 0.10 mg·kg-1 and 0.15 mg·kg-1. The 0.05 mg·kg-1 dose did not always prevent succinylcholine-induced muscle fasciculations. The 0.15 mg·kg-1 dose gave poor conditions for tracheal intubation and was therefore discontinued. The 0.075 mg·kg-1 dose seemed optimal.

Most patients felt transient pain at the site of the injection during administration of fazadinium, and many had a sensation of drowsiness.

Key Words: NEUROMUSCULAR RELAXANTS, Fazadinium, Succinylcholine






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Copyright © 1981 by the Canadian Anesthesiologists' Society.