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Canadian Journal of Anesthesia, Vol 28, 556-560, Copyright © 1981 by Canadian Anesthesiologists' Society

Influence of Serum Protein, Serum Albumin Concentrations and Dose on Midazolam Anaesthesia Induction Times

J. G. REVES 1, PHILIPPA NEWFIELD 2, and LLOYD R. SMITH 3

1 Department of Anaesthesiology; University of California, San Francisco
2 Department of Anaesthesiology, University of California, San Francisco
3 Clinical Cardiology Computer Center, University of Alabama, Birmingham, Alabama

Address for Correspondence: J.G. Reves, M.D., Department of Anaesthesiology, School of Medicine, University of Alabama, Birmingham, Alabama 35294, U.S.A.

Individual variation occurs in time to induction of anaesthesia with intravenous drugs. Less free drug is available to cross the blood-brain barrier when the drug is highly protein bound. Since this may prolong time to sleep, we correlated the induction time, serum albumin and total protein concentrations, and doses of midazolam, which is a highly protein bound intravenous anaesthetic. There is a poor correlation (r = 0.062) between induction time and serum protein, a weak (r = 0.524) but statistically significant (p = 0.026) correlation between induction time and serum albumin, and a highly significant (p = 0.003) negative correlation (r = -0.579) between drug dose and induction time. The administration of the appropriate dose of midazolam for induction, therefore, appears to affect induction time more significantly than does the serum albumin concentration.

Key Words: ANAESTHETICS, INTRAVENOUS, midazolam • PROTEIN BINDING, midazolam • INDUCTION TIME, midazolam






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Copyright © 1981 by the Canadian Anesthesiologists' Society.