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Canadian Journal of Anesthesia, Vol 29, 24-26, Copyright © 1982 by Canadian Anesthesiologists' Society

Epidural {beta}-Endorphin in Treatment of Pain

T. OYAMA 1, S. FUKUSHI 1, and T. JIN 1

1 Department of Anaesthesiology, University of Hirosaki School of Medicine, Hirosaki, Japan

Epidural administration of 3 mg of synthetic {beta}-endorphin produced analgesia in 10 patients with intractable pain due to disseminated cancer. Mean onset of relief of pain was 24 ± 3 minutes and the mean duration of analgesia was 19 ± 3 hours.

The onset of analgesia produced by the epidural injection of {beta}-endorphin was slower and the duration less than those observed after intrathecal injection.

Key Words: ANALGESIA, epidural {beta}-endorphin • PAIN






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Copyright © 1982 by the Canadian Anesthesiologists' Society.