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Canadian Journal of Anesthesia, Vol 29, 55-58, Copyright © 1982 by Canadian Anesthesiologists' Society

Effects of Neostigmine and Pyridostigmine on Serum Cholinesterase Activity

R. K. MIRAKHUR 1, T. D. LAVERY 2, L. P. BRIGGS 3, and R.S. J. CLARKE 4

1 Royal Victoria Hospital, Belfast
2 Biochemistry Laboratory, Royal Victoria Hospital, Belfast
3 Department of Anaesthetics, The Queen's University of Belfast
4 The Queen's University of Belfast

Serum cholinesterase activities were measured for 270 minutes in patients following administration of neostigmine or pyridostigmine for the reversal of pancuronium block in groups of seven patients each. The enzyme activities were significantly depressed by neostigmine for four hours and by pyridostigmine throughout the whole period of study. Whereas the immediate effects of neostigmine were more intense, the effects of pyridostigmine beyond the first 30 minutes were more profound. The clinical relevance of these findings is discussed.

Key Words: ENZYMES, serum cholinesterase • ANTAGONISTS, NEUROMUSCULAR RELAX ANTS, neostigmine, pyridostigmine




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