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Canadian Journal of Anesthesia, Vol 29, 65-67, Copyright © 1982 by Canadian Anesthesiologists' Society

Effect of Protamine on Plasma Ionized Calcium in the Dog

RONALD M. JONES 1, ANNE B. HILL 1, MICHAEL L. NAHRWOLD 1, and ALAN R. TAIT 1

1 Department of Anesthesiology, The University of Michigan Medical Center, Ann Arbor, Michigan 48109 U.S.A.

Address correspondence to Dr. Jones at The City Hospital, Department of Anaesthesia, Hucknall Road, Nottingham, United Kingdom.

Ten anaesthetized, heparinized healthy adult dogs were infused with protamine sulphate 3 mg·kg-1 and plasma ionized calcium was measured. A significant (p < 0.01) decrease in ionized calcium occurred which preceded the maximal reduction in cardiac output and systemic arterial pressure. The clinical implications of these results are discussed.

Key Words: BLOOD, plasma ionized calcium • Protamine






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Copyright © 1982 by the Canadian Anesthesiologists' Society.