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Canadian Journal of Anesthesia, Vol 29, 108-111, Copyright © 1982 by Canadian Anesthesiologists' Society

Intravenous Nitroglycerin Control of Blood Pressure during Resection of Phaeochromocytoma

W. N. McDONALD 1, W. A. DOLL 2, N. SCHMIDT 3, and C. REYNOLDS 4

1 Department of Anaesthesia, University of British Columbia, Vancouver, B.C., Canada
2 Department of Anaesthesia, University of British Columbia, and Head, Department of Anaesthesia, St. Paul's Hospital, Vancouver, B.C., Canada
3 Department of Surgery, University of British Columbia, Vancouver, B.C., Canada
4 Department of Medicine, University of British Columbia, Vancouver, B.C., Canada

The majority of patients presenting for resection of phaeochromocytoma require some form of antihypertenive therapy during operation. Phentolamine and sodium nitroprusside have both been used successfully for this purpose, but each has disadvantages. This report describes the use of intravenous nitroglycerin, a rapidly acting venodilator with no appreciable toxicity, as the sole antihypertensive agent in two patients with phaeochromocytoma and partial alpha adrenergic blockade. Hypertensive episodes were quickly and effectively controlled in each case. There were no hypotensive periods and no side effects.

Key Words: SURGERY, phaeochromocytoma • COMPLICATIONS, hypertensive crisis, nitroglycerin






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Copyright © 1982 by the Canadian Anesthesiologists' Society.