CJA
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Submit a scholarly reply
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by NELSON, T. E.
Right arrow Articles by SCHOCHET, S. S.
Right arrow Search for Related Content
PubMed
Right arrow Articles by NELSON, T. E.
Right arrow Articles by SCHOCHET, S. S., JR.

Canadian Journal of Anesthesia, Vol 29, 163-167, Copyright © 1982 by Canadian Anesthesiologists' Society

Malignant Hyperthermia: A Disease of Specific Myofiber Type?

THOMAS E. NELSON 1 and SYDNEY S. SCHOCHET JR. 2

1 Department of Anesthesiology, The University of Texas Medical Branch, Galveston, Texas 77550, U.S.A.
2 Department of Pathology, West Virginia University Medical Center, Morgantown, West Virginia 26506, U.S.A.

The present study attempts to determine if malignant hyperthermia susceptibility (MHS) is limited to muscles composed predominantly of a single major fiber type. The MHS trapezius muscle (49 per cent type 1 and 51 per cent type 2 fibers) has greater abnormal contracture response to halothane or to caffeine than does MHS gracilis (11 per cent type 1 and 80 per cent type 2 fibers). The dynamic properties (contraction and relaxation times) of MHS trapezius and MHS gracilis are similar, suggesting that the greater contracture response of MHS trapezius to halothane or to caffeine is more biochemical than physiological in origin. The results of this study are discussed in relevance to the diagnosis and to aetiologic investigation of malignant hyperthermia.

Key Words: HYPERTHERMIA, malignant






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1982 by the Canadian Anesthesiologists' Society.