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Canadian Journal of Anesthesia, Vol 29, 218-221, Copyright © 1982 by Canadian Anesthesiologists' Society

The In-Vitro Caffeine Contracture Test: Influence of the Muscle Histochemical Profile on Test Results

A.K. W. BROWNELL 1 and M. SZABO 2

1 Department of Clinical Neurosciences and Medicine, The University of Calgary, Health Sciences Centre, 3330 Hospital Drive N.W., Calgary, Alberta, Canada T2N 4N1
2 The University of Calgary, Health Sciences Centre, 3330 Hospital Drive N.W., Calgary, Alberta, Canada T2N 4N1

In vitro caffeine contracture tests were carried out on whole rat muscle composed primarily of either histochemical type I or type II fibers. Muscles composed primarily of type I fibers developed contractures at lower concentrations of caffeine and had lower caffeine specific concentrations than muscles composed primarily of type II fibers. These findings indicate that the histochemical profile of a muscle can influence the results of the in-vitro caffeine contracture test.

Key Words: MALIGNANT HYPERTHERMIA, In-Vitro Caffeine Contracture Test, Muscle Histochemistry






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Copyright © 1982 by the Canadian Anesthesiologists' Society.