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Canadian Journal of Anesthesia, Vol 29, 231-235, Copyright © 1982 by Canadian Anesthesiologists' Society

Failure of Narcotic Antagonist to Alter Electroacupuncture Modification of Halothane Anaesthesia in the Dog

AYE-AYE L. TAY 1, CHIN-KAI TSENG 1, NATHAN L. PACE 1, K. C. WONG 1, and BENECIA C. HONG-GOKA 1

1 Department of Anesthesiology, University of Utah School of Medicine, 50 North Medical Drive, Salt Lake City, Utah

Correspondence and reprint requests to: Nathan L. Pace, M.D.

Sixteen dogs were used to study the analgesic effects of electroacupuncture. Electroacupuncture lowered halothane MAC significantly (1.21 ± 0.04 to 1.05 ± 0.05 per cent, p < 0.005). Reversibility of this effect by narcotic antagonist was then studied, using naltrexone 5 mg·kg-1 injected intravenously (10 dogs) or 0.5 mg·kg-1 intrathecally (3 dogs). We failed to see any reversal of the effect of electroacupuncture on MAC. Narcotic antagonist reversibility of acupuncture effect is taken currently to imply endorphin mediation. Possible explanations for our result include an electroacupuncture analgesia not mediated by endorphins.

Key Words: ACUPUNCTURE, narcotic antagonist






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Copyright © 1982 by the Canadian Anesthesiologists' Society.