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Canadian Journal of Anesthesia, Vol 29, 243-249, Copyright © 1982 by Canadian Anesthesiologists' Society

Correction of the Unfavourable Effects of Vasopressin by Nitroglycerin Infusion

V. LANZA 1, I. DEMMA 1, A. CALI 1, and G. CASTRONOVO 1

1 Department of Anaesthesia, Surgical Clinic III, University of Palermo, Palermo, Italy

Address for correspondence: Dott. Vincenzo Lanza, Via Libertà 163, 90143 Palermo, Italy.

Nitroglycerin was administered with vasopressin to prevent adverse effects. Vasopressin 0.25U·70kg-1·min-1 was infused intravenously in four dogs for 40 minutes, when a venous infusion of nitroglycerin 1.2 µg·kg-1·min-1 was added for 20 minutes. Nitroglycerin 1.2 µg·kg-1·min-1 alone was infused intravenously in another four dogs for 40 minutes. The venous blood pressures (mesenteric and central) and arterial pressures (mesenteric and femoral), the electrocardiogram and arterio-venous difference were recorded. Nitroglycerin was shown to annul the unfavourable effects of vasopressin without altering its efficacy upon portal pressure.

Key Words: PHARMACOLOGY, vasopressin, nitroglycerin






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Copyright © 1982 by the Canadian Anesthesiologists' Society.