CJA
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Submit a scholarly reply
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by LEE, D. C.
Right arrow Articles by CLIFFORD, D. H.
Right arrow Search for Related Content
PubMed
Right arrow Articles by LEE, D. C.
Right arrow Articles by CLIFFORD, D. H.

Canadian Journal of Anesthesia, Vol 29, 349-354, Copyright © 1982 by Canadian Anesthesiologists' Society

Inhibition of the Cardiovascular Effects of Lysine Acetylsalicylate by Propranolol in Dogs during Halothane Anaesthesia

DO CHIL LEE 1, MYUNG O. LEE 2, and DONALD H. CLIFFORD 3

1 Departments of Anesthesia and Physiology; Medical College of Ohio, C.S. No. 10008, Toledo, Ohio 43699, U.S.A.
2 Division of Laboratory Animal Medicine; Medical College of Ohio, C.S. No. 10008, Toledo, Ohio 43699, U.S.A.
3 Division of Laboratory Animal Medicine and Department of Anatomy; Medical College of Ohio, C.S. No. 10008, Toledo, Ohio 43699, U.S.A.

The cardiovascular effects of lysine acetylsalicylate and/or propranolol were studied in 26 dogs. All animals were maintained under anaesthesia with halothane 0.75 per cent, supplemented by the intravenous administration of succinylcholine to allow controlled ventilation during a two hour period of monitoring. Cardiac output, stroke volume, heart rate, mean arterial pressure, pulse pressure, central venous pressure, total peripheral resistance, pH, Pacoco2, Pao2 and base deficit were measured in each dog.

Lysine acetylsalicylate 50 mg·kg-1, administered alone as a single bolus, significantly (P <0.05) increased the cardiac output and stroke volume and significantly decreased the heart rate, central venous pressure and total peripheral resistance in dogs under halothane anaesthesia. Propranolol hydrochloride 0.5 mg·kg-1 as a single intravenous bolus was followed by a significant decrease in cardiac output, heart rate and mean arterial pressure and a significant increase in central venous pressure and total peripheral resistance. The administration of propranolol prior to lysine acetylsalicylate resulted in a significant decrease in cardiac output and heart rate. Pretreatment with propranolol was effective in inhibiting the positive inotropic effect of lysine acetylsalicylate.

Key Words: ANALGESICS, lysine acetylsalicylate • HEART, lysine acetylsalicylate, propranolol






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1982 by the Canadian Anesthesiologists' Society.