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Canadian Journal of Anesthesia, Vol 29, 381-383, Copyright © 1982 by Canadian Anesthesiologists' Society

The Effect of Oral Castor Oil on the Disposition of Methyprylon in Intoxicated Dogs

PETER R. GWILT 1, MARVIN C. PANKASKIE 1, and JOSEPH J. MITALA 1

1 School of Pharmacy, Ferris State College, Big Rapids, Michigan 49307, U.S.A.

Clinical observations indicate that large oral doses of castor oil are effective in reducing the time of coma resulting from acute intoxication with lipophilic drugs. It has been further suggested that the rate of removal of these drugs from the body is increased by castor oil. In order to investigate the effect of castor oil on the disposition of lipophilic drugs, five dogs were given toxic doses of methyprylon by intravenous infusion. Each dog was treated with a large oral dose of castor oil in a cross-over fashion. No significant difference was observed in the sleep times of the dogs treated with castor oil, or in the methyprylon pharmacokinetics compared to controls.

It was concluded that castor oil does not affect the disposition of methyprylon.

Key Words: PHARMACOKINETICS, lipophilic drugs • methyprylon, castor oil






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Copyright © 1982 by the Canadian Anesthesiologists' Society.