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Canadian Journal of Anesthesia, Vol 29, 463-467, Copyright © 1982 by Canadian Anesthesiologists' Society

Cerebral Vascular Responses to Ketamine and Thiopentone During Foetal Acidosis

BRIAN G. PICKERING M.D.1, RICHARD J. PALAHNIUK M.D.1, JACQUES COTÉ M.D.1, JOHN G. WADE M.D.1, and MICHAEL G. PASH M.D.1

1 Department of Anaesthesia, University of Manitoba, Winnipeg, Manitoba

Reprint requests to: Dr. Richard J. Palahniuk, Department of Anaesthesia, University of Manitoba, AD201, Interne's Residence, 720 McDermot Ave., Winnipeg, Manitoba, R3E 0Z3.

Using a chronic sheep preparation, with induced foetal acidosis, the effects of low and high dose thiopentone and ketamine on maternal and foetal cardiovascular dynamics were studied. Ketamine 4 mg·kg-1 and thiopentone 10 mg·kg-1 were both associated with marked reductions in foetal cerebral blood flow and cerebral oxygen delivery. Blood pressure and cerebral blood flow in the acidotic foetus was better preserved, however, following the lower dose of ketamine 2 mg·kg-1 than following thiopentone 6 mg·kg-1

Key Words: BRAIN, vascular responses, foetal acidosis • ANAESTHESIA, obstetrical, complications, foetal acidosis • ANAESTHETICS, intravenous, ketamine, thiopentone






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Copyright © 1982 by the Canadian Anesthesiologists' Society.