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Canadian Journal of Anesthesia, Vol 29, 481-483, Copyright © 1982 by Canadian Anesthesiologists' Society

Duration of Intradermal Anaesthesia with Mixtures of Bupivacaine and Lidocaine

P. T. SWEET M.B., B.S., (Lond.) F.F.A.R.C.S.1, D. A. MAGEE M.B., B.Ch., F.F.A.R.C.S.I.1, and A.J. C. HOLLAND M.B., B.S., F.F.A.R.C.S., D.C.H.1

1 Department of Anaesthesia, McGill University, The Montreal General Hospital, 1650 Cedar Avenue, Montreal, P.Q., H3G 1A4

In a double-blind trial on 20 human volunteers, the duration of intradermal anaesthesia with bupivacaine 0.25 per cent was compared with duration with a mixture of bupivacaine 0.25 per cent and carbonated lidocaine 1.0 per cent and with a mixture of bupivacaine 0.25 per cent and lidocaine hydrochloride 1.0 per cent.

The duration of intradermal anaesthesia produced by bupivacaine mixed with carbonated lidocaine was 114 ± 56 (mean ± 1 SD) minutes and was not significantly shorter than the duration of the bupivacaine alone, at 125 ± 70 minutes, or duration with the mixture of bupivacaine and lidocaine hydrochloride, which was 112 ± 41 minutes.

These results indicate that the mixture of bupivacaine with either carbonated lidocaine or lidocaine hydrochloride may be used for local anaesthesia without significant shortening of the duration of action.

Key Words: ANAESTHETICS, LOCAL, bupivacaine, lidocaine






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Copyright © 1982 by the Canadian Anesthesiologists' Society.