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Canadian Journal of Anesthesia, Vol 29, 484-488, Copyright © 1982 by Canadian Anesthesiologists' Society

Cardiovascular Collapse Associated with Nitrous Oxide Anaesthetic: A Case Report

JOHN R. DAVIDSON M.D.1 and HERBERT M. CHINYANGA M.D., F.R.C.P.(C)2

1 Department of Anaesthesia, University of Western Ontario, London, Ontario, Canada
2 The Hospital for Sick Children, Department of Anaesthesia, University of Toronto, Toronto, Ontario, Canada

Address for Correspondence and Reprints: Dr. H.M. Chinyanga, Department of Anaesthesia, The Hospital for Sick Children, 555 University Avenue, Toronto, Ont., Canada, M5G 1X8.

This is a case report of a one year old infant weighing 6.7 kilograms with a preoperative diagnosis of partial anomalous pulmonary venous drainage whose anaesthetic was complicated by cardiovascular collapse following addition of nitrous oxide to oxygen administered to the patient using a T-piece breathing circuit. The cardiovascular pathopharmacology of all the drugs administered to the patient before the event as well as that of nitrous oxide is discussed in detail. The drugs discussed are atropine 0.1 mg (0.01 mg·kg-1), glycopyrrolate 0.07 mg (0.01 mg·kg-1), morphine 0.9 mg (0.14 mg·kg-1) methylprednisone sodium succinate 165 mg (23.5 mg·kg-1) sodium thiopentone 40 mg (5.7 mg·kg-1), metocurine 3.4 mg (0.4 mg·kg-1).

Key Words: ANAESTHETICS, GASES, nitrous oxide • COMPLICATIONS, congenital heart disease, cardiovascular collapse






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Copyright © 1982 by the Canadian Anesthesiologists' Society.