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Canadian Journal of Anesthesia, Vol 29, 533-538, Copyright © 1982 by Canadian Anesthesiologists' Society

Haemodynamic and Catecholamine Response to Isoflurane Anaesthesia in Patients Undergoing Coronary Artery Surgery

KANTEERAVA BALASARASWATHI M.D.1, SILAS N. GLISSON Ph.D.1, ADEL A. EL-ETR M.D.2, and NAGAPRASADARAO MUMMANENI M.D.1

1 Department of Anesthesiology, Stritch Scool of Medicine, Loyola University Medical Center, Maywood, Illinois 60153, U.S.A.
2 Department of Anesthesiology, Stritch School of Medicine, Loyola University Medical Center, Maywood, Illinois 60153, U.S.A.

Correspondence and reprint requests to: Silas N. Glisson, Ph.D., Department of Anesthesiology, Loyola University Medical Center, 2160 South First Avenue, Maywood, Illinois 60153, U.S.A.

Haemodynamic and plasma catecholamine responses were evaluated during isoflurane anaesthesia in ten patients undergoing coronary artery bypass surgery. Following thiopentone induction the patients were anaesthetized with isoflurane 1.5-2.0 per cent in oxygen. The results show that after 10 minutes of isoflurane anaesthesia there was a significant increase from baseline in heart rate, 68 to 80; cardiac output, 3.75 to 4.61; and plasma epinephrine, 0.80 to 1.33 µg/l. Conversely, there was a significant reduction in systemic vascular resistance index, 3388 to 2260, and plasma norepinephrine, 1.10 to 0.88 µg/l. Twenty-five minutes later, after sternotomy, heart rate, cardiac output and the level of plasma epinephrine were still elevated, and systemic vascular resistance index and plasma norepinephrine remained lowered (p < 0.05). This study demonstrates significant catecholamine responses during isoflurane anaesthesia. The increase in plasma epinephrine paralleled the increase in heart rate and cardiac output, and the decrease in plasma norepinephrine paralleled the decrease in systemic vascular resistance. Based upon these findings we conclude that catecholamine responses contribute to the cardiac and peripheral cardiovascular changes observed with isoflurane anesthesia.

Key Words: ANAESTHETICS, VOLATILE, isoflurane • ANAESTHESIA, cardiovascular • SYMPATHETIC NERVOUS SYSTEM, catecholamines, epinephrine, norepinephrine • HAEMODYNAMICS






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Copyright © 1982 by the Canadian Anesthesiologists' Society.