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Canadian Journal of Anesthesia, Vol 29, 627-629, Copyright © 1982 by Canadian Anesthesiologists' Society

Malignant Hyperpyrexia and Duchenne Muscular Dystrophy: A Case Report

SHIGEHIRO OKA M.D.1, YOSHIO IGARASHI M.D.1, AKIO TAKAGI M.D.2, MITSUHIRO NISHIDA M.D.1, KAZUO SATO M.D.3, KAZUMASA NAKADA M.D.3, and KAZUYUKI IKEDA M.D.3

1 Department of Paediatrics, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431-31, Japan
2 Department of Anaesthesiology, Division of Neuromuscular Research, National Center for Nervous, Mental and Muscular Disorders, Kodaira, Tokyo 187, Japan
3 Department of Anaesthesiology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431-31, Japan

Address for Correspondence: Shigehiro Oka, M.D., Department of Paediatrics, Hamamatsu University School of Medicine, 3600 Handa-Cho, Hamamatsu-Shi, Shizuoka-Ken 431-31, Japan.

We report a patient with Duchenne muscular dystrophy who developed malignant hyperpyrexia during general anaesthesia. During anaesthesia bradycardia was followed by ventricular fibrillation, on which ventricular flutter supervened and a body temperature rise of 0.6° C for 15 minutes, myoglobinuria and elevation of CPK level were observed. The caffeine sensitivity test of biopsied muscle fibers revealed an increase in sensitivity, although there was no sign of muscle rigidity during or after anaesthesia. Diagnosis of Duchenne muscular dystrophy was first established after the development of malignant hyperpyrexia in the present case as well as in previously reported cases. Determination of serum CPK is very important before general a naesthesia.

Key Words: COMPLICATIONS, malignant hyperpyrexia, Duchenne muscular dystrophy






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Copyright © 1982 by the Canadian Anesthesiologists' Society.