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Canadian Journal of Anesthesia, Vol 29, S53-S56, Copyright © 1982 by Canadian Anesthesiologists' Society

Clinical Evaluation of Isoflurane: Discussion

JAMES B. FORREST

A clinical evaluation of isoflurane was carried out, using a standardized data collection form, on 6,798 patients in 165 University teaching hospitals in North America. The results of this study identified a number of patient related factors such as age, body size, presence of disease, and current drug therapy, as well as anaesthetic related factors such as isoflurane concentration, anaesthetic drugs, and manoeuvres which significantly influenced the clinical response to isoflurane. In addition, numerous demographic relationships have been established which were previously unavailable. The conclusions of the study based on these findings are that isoflurane has an acceptable margin of efficacy and safety and can be used in a wide spectrum of clinical situations. A number of possible specific advantages are suggested which warrant further comparative study.






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Copyright © 1982 by the Canadian Anesthesiologists' Society.