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Canadian Journal of Anesthesia, Vol 3, 39-42, Copyright © 1956 by Canadian Anesthesiologists' Society

Nalorphine in the Prevention of Opiate-Induced Neonatal Narcosis

FREDERICK PRESCOTT PH.D., M.R.C.P. (LOND.)1

1 Wellcome Research Institution, London, England

The use of nalorphine (N-allylnormorphine) as an antagonist to morphine and the opiates is discussed. A dose of 10 mg. in the adult reverses most of the pharmacological actions of clinical doses of the opiates; the dose is critical. Nalorphine can be used to prevent respiratory and circulatory depression in the newborn due to over-dosage of the mother with (drugs such as morphine and demerol. If the baby is born with signs of asphyxia, or it does not breathe readily, 0.5 mg. nalorphine is injected into the umbilical vein. Of the babies treated, 80 per cent gasped within half a minute. It is possible that the use of nalorphine will enable opiate drugs to be used nearer the tune of delivery

Note:

Presented at the Annual Meeting of the Canadian Anaesthetists' Society, Toronto, June 20, 1955.






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Copyright © 1956 by the Canadian Anesthesiologists' Society.