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Canadian Journal of Anesthesia, Vol 3, 326-334, Copyright © 1956 by Canadian Anesthesiologists' Society

The Clinical Usage of Neraval

DERMOT B. O'HERLIHY M.D.1, NOBUO NISHIMURA M.D1, DAVID M. LITTLE Jr. MD1, and RALPH M. TOVELL M.D.1

1 Department of Anesthesiology, Hartford Hospital, Hartford, Connecticut

1. The use of Neraval has been studied during the course of 300 clinical administrations.

2. The induction time of Neraval is more than twice that of Pentothal.

3. Both the induction dose and the total dose of Neraval are 1.7 times that of Pentothal.

4. The effect of Neraval upon the vital medullary centres is similar to that of other ultra-short-acting thiobarbiturates, although there is suggestive evidence that the drug may be less depressing to the respiratory centre.

5. Parasympathetic activity is occasionally quite marked during induction with Neraval, and is manifested by the occurrence of hiccups, coughing, and sneezing or laryngospasm.

6. Concentrations of Neraval above 2.5 per cent may be irritating to the veins into which the drug is injected.

7. Waking time following a sleeping dose of Neraval is shorter than that following Pentothal.

Note:

Presented at the Annual Meeting of the Canadian Anaesthetists' Society, Mont Tremblant, PQ, June 18–20, 1956







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Copyright © 1956 by the Canadian Anesthesiologists' Society.