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Canadian Journal of Anesthesia, Vol 30, 19-23, Copyright © 1983 by Canadian Anesthesiologists' Society

Cardiovascular Effects of Midazolam and Thiopentone for Induction of Anaesthesia in Ill Surgical Patients

PHILIP W. LEBOWITZ MD1, M. ELIZABETH COTE CRNA1, ALFRED L. DANIELS BA1, J.A. JEEVENDRA MARTYN MD1, RICHARD S. TEPLICK MD1, J. KENNETH DAVISON MD1, and N. SUNDER MD1

1 Anesthesia Services of the Massachusetts General Hospital and the Department of Anesthesia, Harvard Medical School, Boston, Massachusetts 02114, USA

Address Correspondence to: Dr. Lebowitz, Department of Anesthesia, Massachusetts General Hospital, Boston, Massachusetts 02114 USA.

The cardiovascular effects of midazolam (0.15 mg kg-1) and thiopentone (3.0 mg kg-1) were compared during induction of anaesthesia in 20 American Society of Anesthesiologists class in patients. In patients given thiopentone (N = 11), cardiac output, mean arterial pressure, heart rate, and systemic vascular resistance all decreased significantly over the course of the study period; mean right atrial pressure rose slightly, and stroke volume remained the same. Patients receiving midazolam (N = 9) experienced similar haemodynamic changes which were significant relative to baseline only for the fall in mean arterial pressure and the rise in mean right atrial pressure at ten minutes. There were no significant differences between the two groups. Midazolam thus appears to be at least as acceptable an induction agent as thiopentone in ill patients, from a haemodynamic point of view.

Key Words: ANAESTHETICS, INTRAVENOUS: midazolam, thiopentone • BLOOD PRESSURE: drug effects • HEART: cardiac output, drug effects






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Copyright © 1983 by the Canadian Anesthesiologists' Society.