CJA
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Submit a scholarly reply
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by SAMRA, S. K.
Right arrow Articles by KOTHARY, S. P.
Right arrow Search for Related Content
PubMed
Right arrow Articles by SAMRA, S. K.
Right arrow Articles by KOTHARY, S. P.

Canadian Journal of Anesthesia, Vol 30, 48-52, Copyright © 1983 by Canadian Anesthesiologists' Society

Modification by Halogenated Anaesthetics of Chronotropic Response during Reversal of Neuromuscular Blockade

SATWANT K. SAMRA MD1, UMA A. PANDIT MD1, SUJIT K. PANDIT MD1, and SARLA P. KOTHARY MD1

1 Department of Anesthesiology, University of Michigan Medical Center, Ann Arbor

Address Correspondence to: Satwant K. Samra MD, Department of Anesthesiology, Box 43, University of Michigan Medical Center, Ann Arbor, MI 48109.

The effect of halothane and enflurane on changes in heart rate during reversal of neuromuscular block was compared in 48 adult patients. Premedication and anaesthetic technique were standardized. Either halothane or enflurane was the primary anaesthetic while pancuronium was used in all patients to achieve muscle relaxation. Ventilation was mechanically controlled and PaCO2 was between 30-40 mmHg. The neuromuscular block was reversed by an intravenous injection ofatropine 1.2 mg and neostigmine 2.5 mg, given either separately or simultaneously, in different patient subgroups. Heart rate changes were significantly different between the halothane and enflurane groups. In general, reversal of neuromuscular block was accompanied by less fluctuations in heart rate after enflurane as compared to halothane anaesthesia. Simultaneous injection ofatropine and neostigmine modified the tachycardiac response in the halothane sub-group only. Our observations suggest that use of enflurane offers an advantage over halothane in those patients in whom rapid fluctuations in heart rate during reversal of neuromuscular block may be dangerous.

Key Words: ANTAGONISTS, NEUROMUSCULAR RELAXANTS: neostigmine • HEART: pulse rate • ANAESTHETICS, VOLATILE: halothane, enflurane






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1983 by the Canadian Anesthesiologists' Society.