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Canadian Journal of Anesthesia, Vol 30, 162-165, Copyright © 1983 by Canadian Anesthesiologists' Society

Measurement of Plasma Fentanyl Concentration: Comparison of Three Methods

J. A. PHIPPS MB BS FFARCS1, M. A. SABOURIN RT BSC1, W. BUCKINGHAM DIPL BIOL SCI1, and L. STRUNIN MD FFARCS FRCP(C)1

1 Department of Anaesthesia, University of Calgary

Address Correspondence to: Dr. L. Strunin, Department of Anaesthesia, Foothills Hospital, 1403, 29th Street N.W., Calgary, Alberta, T2N 2T9.

The measurement of plasma fentanyl concentration by radioimmunoassay (RIA) and gas liquid chromatography (GLC) using either aflame ionization detector (FID) or nitrogenlphosphorus detector (NPD) has been compared. RIA is a satisfactory but expensive method of measuring plasma fentanyl concentration. GLC using an FID is not as satisfactory as RIA, but when an NPD is used the results are equal to those of RIA. In addition, other analgesics which are chemically similar to fentanyl, such as alfentanil, may also be measured by the GLC/NPD combination using the same set of operating conditions. By contrast, an RIA method is usually specific for only one compound, and measurement of additional drugs would almost certainly necessitate the development of new assay kits for each one.

Key Words: MEASUREMENT TECHNIQUES: gas chromatography, radioimmunoassay • ANALGESICS: fentanyl






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Copyright © 1983 by the Canadian Anesthesiologists' Society.