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Canadian Journal of Anesthesia, Vol 30, 230-234, Copyright © 1983 by Canadian Anesthesiologists' Society

Murine auto- and cross-tolerance to volatile anaesthetics

JACK CHALON MD1, CHAU-KVEI TANG MD1, CRAIG ROBERTS BA1, LAURA WALPERT BA1, CHERYL HOFFMAN 1, SIVAM RAMANATHAN MD1, and HERMAN TURNDORF MD1

1 Department of Anesthesiology, New York University Medical Center, New York, N.Y.

Address Correspondence to: Jack Chalon, MD, 9 Tarryhill Road, Tarrytown, N.Y. 10591, U.S.A.

Auto-tolerance and cross-tolerance to halothane, isoflurane and enflurane were tested on 36 mice divided into three equal groups. Each group was first exposed to increasing concentrations of either of the three anaesthetics on 13 occasions. The concentration at which each mouse lost its righting reflex during successive exposures in a rotating cage was noted. Cross-tolerance was assessed by comparing the number of mice which had lost their righting reflexes during their first exposure to a given anaesthetic agent to the number which lost it after having been exposed to another anaesthetic.

All animals developed auto-tolerance to halothane, isoflurane and enflurane. Cross-tolerance was noted only between mice exposed to isoflurane and enflurane and between mice exposed to halothane and subsequently anaesthetized with isoflurane, but not vice versa.

Key Words: ANAESTHETICS, VOLATILE: halothane, isoflurane, enflurane • POTENCY, ANAESTHETIC: tolerance






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Copyright © 1983 by the Canadian Anesthesiologists' Society.