CJA
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Submit a scholarly reply
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by KRIPKE, B. J.
Right arrow Articles by GRUENER, R.
Right arrow Search for Related Content
PubMed
Right arrow Articles by KRIPKE, B. J.
Right arrow Articles by GRUENER, R.

Canadian Journal of Anesthesia, Vol 30, 290-294, Copyright © 1983 by Canadian Anesthesiologists' Society

Association of Postanaesthetic Hyperthermia with Abnormal Muscle Characteristics: A Case Report

BENJAMIN J. KRIPKE MD1, THOMAS J. J. BLANCK MD PHD1, DAVID A. SIZEMORE MD PHD1, FRANCIS L. COMUNALE MD1, JUDY CHRISTIANSEN MSC1, and RAPHAEL GRUENER PHD1

1 Department of Anesthesiology, San Bernardino County Medical Center, San Bernardino, California and the Departments of Physiology and Anesthesiology, University of Arizona Health Sciences Center, Tucson, Arizona

Address Correspondence to: Dr. Benjamin J. Kripke, Department of Anesthesiology, San Bernardino County Medical Center, 780 E. Gilbert Street, San Bernardino, CA 92404.

A previously healthy 18-year-old male, following appendectomy eveloped post-anaesthetic hyperthermia (42.1° C) with an elevation of serum creatine kinase and activated partial thromboplastin time. Repeated arterial blood gases were normal. Cooling and anti-pyretic medication did not control the fever. In contrast, sodium dantrolene appeared effective in lowering the patient's temperature and normalizing the vital signs, both acutely and over the following three days. Subsequent muscle biopsy revealed a normal contracture response to caffeine alone or in the presence of halothane. However, the muscle had a larger than normal potentiation of evoked twitch tension in the presence of caffeine and halothane. Electrophoresis of the muscle revealed a marked increase of an unidentified low molecular weight protein. The patient's clinical course, and the results of the muscle studies, sugest that an abnormality of skeletal muscle, other than that seen in the classic malignant hyperthermia syndrome may result in anaesthesia-related hyperthermia.

Key Words: HYPERTHERMIA: following anaesthesia, dantrolene • MUSCLE, SKELETAL: electrophoresis






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1983 by the Canadian Anesthesiologists' Society.