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Canadian Journal of Anesthesia, Vol 30, 487-492, Copyright © 1983 by Canadian Anesthesiologists' Society

Placental Transport of Metoclopramide: Assessment of Maternal and Neonatal Effects

M. BYLSMA-HOWELL MD1, K. W. RIGGS BSC MSC1, G. H. McMORLAND MB CHB RCPS FRCP(C)1, D. W. RURAK PHD1, R. ONGLEY MD FRCP(C)1, B. McERLANE BSC RT1, J.D. E. PRICE MD FRCP(C)FACP1, and J. E. AXELSON PHD1

1 Faculty of Pharmaceutical Sciences and Medicine, University of British Columbia, Vancouver, B.C

Address correspondence to: Dr. J.E. Axelson, 2146 East Mall, University of British Columbia, Vancouver, B.C. V6T 1W5

Twenty-three patients undergoing general anaesthesia for Caesarian section for healthy term pregnancies were entered into a double blind study using metoclopramide (MCP) and a normal saline placebo. Of these patients, eight received intravenous metoclopramide, 12 a normal saline placebo and three were lost to clinical follow-up. The maternal gastric volumes were measured and maternal and foetal MCP plasma concentrations were determined by gas-liquid chromatography. The Neurological and Adaptive Capacity Score tests ofAmiel, Barrier and Schnider (NACS) were used to attempt evaluation of neonatal responses to MCP. Maternal gastric volume was significantly lower (p < 0.05) in the treated patients. There were no marked differences in Apgar scores, cardiovascular parameters or neurobehavioural scores between the treated and untreated groups of neonates. At no time were the foetal metoclopramide plasma concentrations observed to exceed maternal values.

Key Words: PREMEDICATION: metoclopramide, placental transport, foetal effects






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Copyright © 1983 by the Canadian Anesthesiologists' Society.