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Canadian Journal of Anesthesia, Vol 30, 517-521, Copyright © 1983 by Canadian Anesthesiologists' Society

Nalbuphine Versus Meperidine for Postoperative Analgesia: A Double-Blind Comparison Using the Patient Controlled Analgesic Technique

JOHN S. SPRIGGE MB BCHIR FFARCS1 and PAUL E. OTTON MD FRCP(C)1

1 Department of Anaesthesia, Royal Victoria Hospital, Montreal, Quebec

Address correspondence to: Dr. P.E. Otton, Anaesthetist-in-Chief, Royal Victoria Hospital, 687 Pine Avenue West, Montreal, Que., H3A 1A1.

A double-blind study was undertaken to compare nalbuphine, a synthetic partial agonist opiate, with meperidine in providing analgesia in patients following abdominal surgery, using the patient controlled analgesic technique. Both drugs showed a wide variation in demand requirements, but they were equally effective in relieving pain as assessed by the linear analogue technique. Neither drug caused a reduction of respiratory rate. The patient-controlled analgesic technique gave analgesia of good quality and it aided the comparison of the two drugs. However, some of the patients found the technique difficult to manage, and it is expensive and timeconsuming. Until further experience is gained with this device its use should be confined to a constant care unit.

Key Words: PAIN: postoperative • ANALGESIA: patient demand • ANALGESICS: nalbuphine, meperidine






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Copyright © 1983 by the Canadian Anesthesiologists' Society.