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Canadian Journal of Anesthesia, Vol 30, 522-525, Copyright © 1983 by Canadian Anesthesiologists' Society

Cell-Mediated Immune Suppression Due to Alfathesin in Short-Term Anaesthesia

A. ROSENFELD MD1, Z. T. HANDZEL MD1, S. KONICHEZKY MD1, S. LEVIN MB CHB1, and D. SOROKER MD1

1 Departments of Anaesthesiology and Paediatrics, Kaplan Hospital Rehovot, and the Hebrew University, Hadassah Medical School, Jerusalem, Israel

Address correspondence to: Dr. D. Soroker, Kaplan Hospital, 76-100 Rehovot, Israel.

The immunosuppressive effects on cell-mediated immunity of alfathesin, when used as the sole agent for short-term anaesthesia, were investigated in ten women undergoing pregnancy termination. Cell-mediated immunity was evaluated by E rosette formation in peripheral blood (reflecting the percentage of T lymphocytes) and by proliferative responses to the mitogens concanavalin A and phyto-haemagglutinin in various concentrations. Measurements were made before alfathesin was administered, and again after 60 minutes, two days and seven days. Significant reductions in the percentage of E rosettes in peripheral blood and in mitogenic responses to concanavalin A were observed 60 minutes after administration of alfathesin. A model is proposed in which alfathesin binds to lymphocytic membrane receptors, thus affecting in vitro cell-mediated immune reactions.

Key Words: ANAESTHETICS • INTRAVENOUS • alfathesin • immunity • cellular






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Copyright © 1983 by the Canadian Anesthesiologists' Society.