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Canadian Journal of Anesthesia, Vol 30, 603-606, Copyright © 1983 by Canadian Anesthesiologists' Society

Oral Diazepam Premedication Reduces the Incidence of Post Succinylcholine Muscle Pains

ANDREW O. DAVIES MD FRCP(C)1

1 Departments of Anaesthesia, North Bay Civic Hospital, and St. Joseph's General Hospital, North Bay, Ont.

Address correspondence to: Dr. A.O. Davies, 1140 Glenwood Rd., North Bay, Ontario, Canada P1B 4S5.

In a prospective, double-blind placebo controlled trial, the effect of oral diazepam premedication on post-succinylcholine fasciculations and myalgia was studied. Forty patients undergoing septoplasty procedures received orally identical capsules containing either 10 mg of diazepam or a placebo 90 minutes preoperatively. A standardized anaesthetic regimen included induction with 5 mg·kg-1 of thiopental and 1 mg·kg-1 of succinylcholine. The diazepam and control groups did not differ significantly in extent of fasciculations or ease of intubation. However, only 15 per cent of the diazepam premedicated patients had myalgias postoperatively compared to 50 per cent of the control patients, a statistically significant difference (p = 0.04).

Key Words: PREANAESTHETIC MEDICATION: diazepam • NEUROMUSCULAR RELAXANTS: succinylcholine, adverse effects






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Copyright © 1983 by the Canadian Anesthesiologists' Society.